Rett Syndrome: What Do General Pediatric Providers Need to Know to Enhance Care? (Archived CME/CE Monograph)

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Activity Description and Purpose

Pediatricians, nurse practitioners, and physician assistants in the primary care setting are responsible for the ongoing care of patients with Rett syndrome. Because of the rareness of the disorder, pediatric clinicians need education on best practices and multidisciplinary care of these complex patients. This educational activity will provide them with the skills to identify subtle signs and symptoms of Rett syndrome during the early stages of the disorder so that referral can be made in a timely manner. Pediatric clinicians will also become familiar with the guidelines that are important for this disease so they may consistently practice guideline-based multidisciplinary care. Finally, experts will provide a clear breakdown of the clinical data for the newly approved treatment trofinetide and the emerging agent blarcamesine.

Target Audience

This educational activity is intended for general pediatricians, nurse practitioners, and physician assistants.

Learning Objectives

After completing this activity, participants will be better able to:

  • Identify subtle signs and symptoms of Rett syndrome during the early stages of the disorder
  • Identify guidelines used for patients with Rett syndrome
  • Employ guideline-based multidisciplinary care to individualize care of patients with Rett syndrome
  • Analyze recent clinical trial data of new and emerging disorder-specific therapies for Rett syndrome
Course summary
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Jeffrey L. Neul, MD, PhD (Chair)
Annette Schaffer Eskind Chair and Director
Vanderbilt Kennedy Center
Professor of Pediatrics
Division of Neurology, Pharmacology, and Special Education
Vanderbilt University Medical Center
Nashville, Tennessee

Arthur Beisang, MD
Complex Care Pediatrician
Gillette Children’s
St Paul, Minnesota

Constance L. Smith-Hicks, MD, PhD
Neurologist and Research Scientist
Kennedy Krieger Institute
Baltimore, Maryland

Disclosure Policy

MedEdicus adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers, or others, are required to disclose all financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been identified and mitigated by MedEdicus prior to the commencement of the activity.


Arthur Beisang, MD, is an advisory board member of ACADIA Pharmaceuticals Inc.

Jeffrey L. Neul, MD, PhD, is a consultant for F. Hoffmann-La Roche Ltd, Jazz Pharmaceuticals Inc, Myrtelle, Inc, and Taysha GTx; and is an advisory board member of Alcyone Therapeutics and Ovid Therapeutics.

Constance L. Smith-Hicks, MD, PhD, has no relevant commercial relationships to disclose.

Peer Reviewer

This activity was peer reviewed. The peer reviewer has no relevant commercial relationships to disclose.

Planners, Managers, and Writers

Carrie Allen, PharmD, BCPP, BCPS, MedEdicus Content Manager for this activity, was previously employed by CVS within the past 2 years, but that relationship has ended.

Other MedEdicus and Amedco planners, managers, and writers have no relevant commercial relationships to disclose.

Satisfactory Completion 

Learners must take the pretest, read the monograph, and complete the posttest and evaluation form to receive a certificate of completion. You must complete the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

For Physicians

ACCME Accreditation Statement

MedEdicus LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA PRA Credit Designation Statement

MedEdicus LLC designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For Nurses

Interprofessional Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by MedEdicus LLC and Amedco LLC. Amedco LLC is jointly accredited by the ACCME, the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Amedco Joint Accreditation #4008163.

Nurses (ANCC) Credit Designation

Amedco LLC designates this activity for a maximum of 1.5 ANCC contact hours.

Nurse Practitioners

The American Association of Nurse Practitioners (AANP) recognizes the Accreditation Council for Continuing Medical Education (ACCME) and the American Nurses Credentialing Center (ANCC) as approved accreditors and allow reciprocity for AANPCP continuing education credit.

Disclosure of Commercial Support

This continuing medical education activity is supported through an educational grant from ACADIA Pharmaceuticals Inc.

Off-Label Discussion

This educational activity may include discussion of unlabeled and/or investigational uses of drugs and devices. Please refer to the official prescribing information for each drug or device discussed in this activity for approved dosing, indications, and warnings.

Provider Contact Information

For questions about this educational activity, please contact MedEdicus LLC at


The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of MedEdicus LLC, Amedco LLC, or ACADIA Pharmaceuticals Inc.

©2023 MedEdicus LLC. 287

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This educational activity has expired. You will not be able to claim credit for this activity.