Meeting the Needs of Patients With Moderate to Severe Ulcerative Colitis: Novel Targets Mean New Opportunities (CME/CE Monograph)
Activity Description and Purpose
Ulcerative colitis (UC) is a chronic inflammatory condition characterized by abdominal cramping, bloody stools, tenesmus, and urgency. Manifesting most often in adolescence and early adulthood, UC exhibits considerable clinical heterogeneity and frequently detracts from patient-related quality of life. Although the quantity and quality of options to treat UC has risen over time, opportunities remain to optimize care for those diagnosed with this highly disruptive disease. This educational activity summarizes strategies and considerations presented during a CME/CE symposium on May 21, 2021, during Digestive Disease Week 2021 and distributed with Gastroenterology. The desired results of this educational activity are to improve the care of patients living with UC.
This educational activity is intended for gastroenterologists, gastroenterology physician assistants, and nurse practitioners involved in the care of patients with ulcerative colitis.
After completing this activity, participants will be better able to:
- Discuss the importance of considering the effect of ulcerative colitis on patients’ quality of life
- Integrate disease activity and quality of life assessments into routine management of ulcerative colitis
- Describe the limitations associated with current treatments for moderate to severe ulcerative colitis
- Review current guidelines for treatment escalation as part of the management of moderate to severe ulcerative colitis
- Summarize recent clinical trials on emerging S1P treatments in ulcerative colitis
- Identify patients who would be good candidates for treatment with S1P modulators if and when they are approved
|William J. Sandborn, MD (Chair)|
Distinguished Professor of Medicine
Division of Gastroenterology
University of California, San Diego
La Jolla, California
|Marla C. Dubinsky, MD|
Professor of Pediatrics and Medicine
Chief, Pediatric Gastroenterology and Nutrition
Mount Sinai Kravis Children’s Hospital
Co-Director, Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center
Icahn School of Medicine at Mount Sinai
New York, New York
|David T. Rubin, MD|
Joseph B. Kirsner Professor of Medicine
Chief, Section of Gastroenterology, Hepatology, and Nutrition
University of Chicago
MedEdicus requires that anyone who is in a position to control the content of this educational activity disclose all relevant financial relationships with any commercial interest. Financial relationship information is collected and resolved prior to the educational activity.
Marla C. Dubinsky, MD, is a consultant for AbbVie Inc, Arena Pharmaceuticals, Inc, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, Celgene Corporation, Eli Lilly and Company, F. Hoffmann-La Roche Ltd, Genentech, Inc, Gilead, Janssen Global Services, LLC, Pfizer Inc, Prometheus Biosciences, Takeda Pharmaceuticals USA, Inc, and UCB SA; is a contracted researcher for AbbVie Inc, Janssen Global Services, LLC, Pfizer Inc, and Prometheus Biosciences; has ownership interest in Trellus Health Inc; and receives other funding (licensing fee) from Takeda Pharmaceuticals USA, Inc.
David T. Rubin, MD, is a consultant for AbbVie Inc, AbGenomics, Allergan, Arena Pharmaceuticals, Inc, Atlantica, Bellatrix Pharmaceuticals, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, CDx Diagnostics, Celgene Corporation, Check-Cap, Dizal Pharmaceutical, Eli Lilly and Company, F. Hoffmann-La Roche Ltd, Galen Limited, Genentech, Inc, Gilead, Ichnos Sciences, InDex Pharmaceuticals Holding AB, Iterative Scopes, Inc, Janssen Global Services, LLC, Materia Prima, Pfizer Inc, Prometheus Laboratories, Reistone Biopharma, Takeda Pharmaceuticals USA, Inc, and Techlab, Inc; and receives grant support from Takeda Pharmaceuticals USA, Inc.
William J. Sandborn, MD, is a consultant for AbbVie Inc, Abivax, Admirx Inc, Alfasigma SpA, Alimentiv, Alivio Therapeutics, Allakos Inc, Amgen Inc, Applied Molecular Transport Inc, Arena Pharmaceuticals, Inc, Bausch & Lomb Incorporated, BeiGene, Bellatrix Pharmaceuticals, Boehringer Ingelheim International GmbH, Boston Pharmaceuticals, Bristol-Myers Squibb Company, Celgene Corporation, Celltrion, Celularity Inc, Cosmo Pharmaceuticals NV, Eli Lilly and Company, Equillium, Inc, Escalier Biosciences BV, F. Hoffmann-La Roche Ltd, Forbion, Genentech, Inc, Gilead, Glenmark Pharmaceuticals, Gossamer Bio, Immunic, Inc, InDex Pharmaceuticals Holding AB, Intact Therapeutics, Inc, Janssen Global Services, LLC, Kyverna Therapeutics, Inc, Landos Biopharma, Inc, Oppilan Pharma, Otsuka America Pharmaceutical, Inc, Pandion Therapeutics, Pfizer Inc, Progenity, Inc, Prometheus Biosciences, Protagonists Therapeutics, Inc, Provention Bio, Inc, Reistone Biopharma, Salix Pharmaceuticals, Inc, Seres Therapeutics, Shanghai Pharma Biotherapeutics USA, Inc, Shire, Shoreline Biosciences, Sublimity Therapeutics, Surrozen, Takeda Pharmaceuticals USA, Inc, Theravance Biopharma, Inc, Thetis Pharmaceuticals LLC, Tillotts Pharma AG, UCB SA, Vedanta Biosciences, Inc, Ventyx Biosciences, Inc, Vimalan Biosciences, Inc, Vivelix Pharmaceuticals, Vivreon Biosciences, and Zealand Pharma A/S; is a contracted researcher for AbbVie Inc, Abivax, Arena Pharmaceuticals, Inc, Boehringer Ingelheim International GmbH, Celgene Corporation, Eli Lilly and Company, Genentech, Inc, Gilead, GlaxoSmithKline, Janssen Global Services, LLC, Pfizer Inc, Prometheus Biosciences, Seres Therapeutics, Shire, Takeda Pharmaceuticals USA, Inc, and Theravance Biopharma, Inc; and has ownership interest (stocks) in Allakos Inc, BeiGene, Gossamer Bio, Oppilan Pharma, Prometheus Biosciences, Progenity, Inc, Shoreline Biosciences, Ventyx Biosciences, Inc, Vimalan Biosciences, Inc, and Vivreon Biosciences.
This activity was peer reviewed by an independent reviewer not affiliated with Gastroenterology. The peer reviewer has no relevant commercial relationships to disclose.
Planners and Managers
MedEdicus planners and managers have no relevant commercial relationships to disclose.
ACCME Accreditation Statement
MedEdicus LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
AMA PRA Credit Designation Statement
MedEdicus LLC designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Interprofessional Joint Accreditation Statement
In support of improving patient care, Amedco LLC is jointly accredited by the ACCME, the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Amedco LLC designates this activity for a maximum of 1.5 ANCC contact hours.
Disclosure of Commercial Support
This continuing medical education activity is supported through an educational grant from Arena Pharmaceuticals, Inc.
This educational activity may include discussion of unlabeled and/or investigational uses of drugs or devices. Please refer to the official prescribing information for each drug or device discussed in this activity for approved dosing, indications, and warnings.
Provider Contact Information
For questions about this educational activity, please contact MedEdicus LLC at firstname.lastname@example.org.
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of MedEdicus LLC; Arena Pharmaceuticals, Inc; the American Gastroenterological Association; or Gastroenterology.
This CME/CE activity is copyrighted to MedEdicus LLC ©2021. All rights reserved. 243b
- 1.50 AMA PRA Category 1 Credit™
- 1.50 ANCC
- 1.50 Participation